Respiratory Research (2024)

Table of Contents
Influenza A, Influenza B, human respiratory syncytial virus and SARSCoV-2 molecular diagnostics and epidemiology in the post COVID-19 era Heterogeneity in PD-L1 expression between primary and metastatic lymph nodes: a predictor of EGFR-TKI therapy response in non-small cell lung cancer A systematic review of machine learning models for management, prediction and classification of ARDS Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway The effect of inhaler prescription on the development of lung cancer in COPD: a nationwide population-based study Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD Expression of glucocorticoid receptor and HDACs in airway smooth muscle cells is associated with response to steroids in COPD Incidence rate of occult lymph node metastasis in clinical T1−2N0M0 small cell lung cancer patients and radiomic prediction based on contrast-enhanced CT imaging: a multicenter study Correction to: Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples Snoring-generated fluid droplets as a potential mechanistic link between sleep-disordered breathing and pneumonia Highly diverse sputum microbiota correlates with the disease severity in patients with community-acquired pneumonia: a longitudinal cohort study Clinical and prognostic associations of anti-Jo-1 antibody levels in patients with antisynthetase syndrome Unveiling the metabolic landscape of pulmonary hypertension: insights from metabolomics Identification of differentially expressed ER stress-related genes and their association with pulmonary arterial hypertension Rates of bronchopulmonary dysplasia in very low birth weight neonates: a systematic review and meta-analysis PD-1+ T lymphocyte proportions and hospitalized exacerbation of COPD: a prospective cohort study Identifying potential drug targets for idiopathic pulmonary fibrosis: a mendelian randomization study based on the druggable genes Improved pediatric ICU mortality prediction for respiratory diseases: machine learning and data subdivision insights Combination of betulinic acid and EGFR-TKIs exerts synergistic anti-tumor effects against wild-type EGFR NSCLC by inducing autophagy-related cell death via EGFR signaling pathway Independent relationship between sleep apnea-specific hypoxic burden and glucolipid metabolism disorder: a cross-sectional study Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells Comparative microbiome analysis in cystic fibrosis and non-cystic fibrosis bronchiectasis. GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis Long COVID symptoms after 8-month recovery: persistent static lung hyperinflation associated with small airway dysfunction The prevalence and mortality risks of PRISm and COPD in the United States from NHANES 2007–2012 Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort Machine-learning developed an iron, copper, and sulfur-metabolism associated signature predicts lung adenocarcinoma prognosis and therapy response Acod1/itaconate activates Nrf2 in pulmonary microvascular endothelial cells to protect against the obesity-induced pulmonary microvascular endotheliopathy Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients Cross-site validation of lung cancer diagnosis by electronic nose with deep learning: a multicenter prospective study Mitochondrial DNA in bronchoalveolar lavage fluid is associated with the prognosis of idiopathic pulmonary fibrosis: a single cohort study GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage Feasibility of restricting e-cigarettes to prescription only for smoking cessation A comprehensive study on machine learning models combining with oversampling for bronchopulmonary dysplasia-associated pulmonary hypertension in very preterm infants Tuberculous pleural effusion-induced Arg-1+ macrophage polarization contributes to lung cancer progression via autophagy signaling Predictors of moderate to severe obstructive sleep apnea in patients with lung cancer Increased proportions of circulating PD-1+ CD4+ memory T cells and PD-1+ regulatory T cells associate with good response to prednisone in pulmonary sarcoidosis Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis Objective monitoring tools for improved management of childhood asthma Cooperation of immune regulators Tollip and surfactant protein A inhibits influenza A virus infection in mice Charting the cellular landscape of pulmonary arterial hypertension through single-cell omics Smoking status and clinical outcome in idiopathic pulmonary fibrosis: a nationwide study Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality Potential role of SIRT-1 and SIRT-3 as biomarkers for the diagnosis and prognosis of idiopathic pulmonary fibrosis TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells Predicting lung function decline in cystic fibrosis: the impact of initiating ivacaftor therapy Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis Respiratory symptoms and outcomes among cigar smokers: findings from the Population Assessment of Tobacco and Health (PATH) study waves 2–5 (2014–2019)

  • Influenza A, Influenza B, human respiratory syncytial virus and SARSCoV-2 molecular diagnostics and epidemiology in the post COVID-19 era

    The concurrent circulation of SARS-CoV-2 with other respiratory viruses is unstoppable and represents a new diagnostic reality for clinicians and clinical microbiology laboratories. Multiplexed molecular testi...

    Authors: Manca Luštrek, Zala Cesar, Alen Suljič, Rok Kogoj, Nataša Knap, Monika Jevšnik Virant, Tina Uršič, Miroslav Petrovec, Tatjana Avšič-Županc and Miša Korva

    Citation: Respiratory Research 2024 25:234

    Content type: Research Published on: 5 June 2024

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  • Heterogeneity in PD-L1 expression between primary and metastatic lymph nodes: a predictor of EGFR-TKI therapy response in non-small cell lung cancer

    There is inconclusive evidence to suggest that the expression of programmed cell death ligand 1 (PD-L1) is a putative predictor of response to EGFR-TKI therapy in advanced EGFR-mutant non-small cell lung cance...

    Authors: Yaohua Hu, Yidan Zhang, You Lu, Yingqi Xu, Jianlin Xu, Hua Zhong, Lei Cheng and Runbo Zhong

    Citation: Respiratory Research 2024 25:233

    Content type: Research Published on: 5 June 2024

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  • A systematic review of machine learning models for management, prediction and classification of ARDS

    Acute respiratory distress syndrome or ARDS is an acute, severe form of respiratory failure characterised by poor oxygenation and bilateral pulmonary infiltrates. Advancements in signal processing and machine ...

    Authors: Tu K. Tran, Minh C. Tran, Arun Joseph, Phi A. Phan, Vicente Grau and Andrew D. Farmery

    Citation: Respiratory Research 2024 25:232

    Content type: Review Published on: 4 June 2024

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  • Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery

    Precision Cut Lung Slices (PCLS) have emerged as a sophisticated and physiologically relevant ex vivo model for studying the intricacies of lung diseases, including fibrosis, injury, repair, and host defense m...

    Authors: Cynthia Koziol-White, Eric Gebski, Gaoyaun Cao and Reynold A. Panettieri Jr.

    Citation: Respiratory Research 2024 25:231

    Content type: Review Published on: 1 June 2024

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  • Targeting lysyl oxidase like 2 attenuates OVA-induced airway remodeling partly via the AKT signaling pathway

    Airway epithelium is an important component of airway structure and the initiator of airway remodeling in asthma. The changes of extracellular matrix (ECM), such as collagen deposition and structural disturban...

    Authors: Rong Zeng, Dong Zhang, Jintao Zhang, Yun Pan, Xiaofei Liu, Qian Qi, Jiawei Xu, Changjuan Xu, Shuochuan Shi, Junfei Wang, Tian Liu and Liang Dong

    Citation: Respiratory Research 2024 25:230

    Content type: Research Published on: 1 June 2024

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  • The effect of inhaler prescription on the development of lung cancer in COPD: a nationwide population-based study

    COPD is associated with the development of lung cancer. A protective effect of inhaled corticosteroids (ICS) on lung cancer is still controversial. Hence, this study investigated the development of lung cancer...

    Authors: Ji Eun Park, Eunyoung Lee, Dave Singh, Eun Kyung Kim, Bumhee Park and Joo Hun Park

    Citation: Respiratory Research 2024 25:229

    Content type: Research Published on: 31 May 2024

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  • Nebulised interferon beta-1a (SNG001) in the treatment of viral exacerbations of COPD

    Respiratory viral infections are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon-β is naturally produced in response to viral infection, limiting replication. This explo...

    Authors: Phillip D. Monk, Jody L. Brookes, Victoria J. Tear, Toby N. Batten, Clare Newall, Marcin Mankowski, Michael G. Crooks, Dave Singh, Rekha Chaudhuri, Brian Leaker, Kerry Lunn, Sophie Reynolds, Sarah Dudley, Felicity J. Gabbay, Stephen T. Holgate, Ratko Djukanovic…

    Citation: Respiratory Research 2024 25:228

    Content type: Research Published on: 29 May 2024

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  • Expression of glucocorticoid receptor and HDACs in airway smooth muscle cells is associated with response to steroids in COPD

    Steroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD) presents a problem for controlling the chronic inflammation of the airways. The glucocorticoid receptor (GR) mediates the intracellular sig...

    Authors: Liang Zhou, Michael Roth, Eleni Papakonstantinou, Michael Tamm and Daiana Stolz

    Citation: Respiratory Research 2024 25:227

    Content type: Research Published on: 29 May 2024

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  • Incidence rate of occult lymph node metastasis in clinical T1−2N0M0 small cell lung cancer patients and radiomic prediction based on contrast-enhanced CT imaging: a multicenter study

    This study aimed to explore the incidence of occult lymph node metastasis (OLM) in clinical T1 − 2N0M0 (cT1 − 2N0M0) small cell lung cancer (SCLC) patients and develop machine learning prediction models using pre...

    Authors: Xu Jiang, Chao Luo, Xin Peng, Jing Zhang, Lin Yang, Li-Zhi Liu, Yan-Fen Cui, Meng-Wen Liu, Lei Miao, Jiu-Ming Jiang, Jia-Liang Ren, Xiao-Tang Yang, Meng Li and Li Zhang

    Citation: Respiratory Research 2024 25:226

    Content type: Research Published on: 29 May 2024

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  • Correction to: Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples

    Authors: Cecilia Brettoni, Alessandro Muzzi, Simona Rondini, Vincent Weynants and Silvia Rossi Paccani

    Citation: Respiratory Research 2024 25:225

    Content type: Correction Published on: 29 May 2024

    The original article was published in Respiratory Research 2023 24:243

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  • Snoring-generated fluid droplets as a potential mechanistic link between sleep-disordered breathing and pneumonia

    The soft palate and back of the throat represent vulnerable early infection sites for SARS-CoV-2, influenza, streptococci, and many other pathogens. We demonstrate that snoring causes aerosolization of pharyng...

    Authors: Tayeb Kakeshpour, Kevin P. Fennelly and Adriaan Bax

    Citation: Respiratory Research 2024 25:224

    Content type: Correspondence Published on: 29 May 2024

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  • Highly diverse sputum microbiota correlates with the disease severity in patients with community-acquired pneumonia: a longitudinal cohort study

    Community-acquired pneumonia (CAP) is a common and serious condition that can be caused by a variety of pathogens. However, much remains unknown about how these pathogens interact with the lower respiratory co...

    Authors: Jing Yang, Jinman Li, Linfeng Zhang, Zijie Shen, Yan Xiao, Guoliang Zhang, Mingwei Chen, Fuhui Chen, Ling Liu, Ying Wang, Lan Chen, Xinming Wang, Li Zhang, Lu Wang, Zhang Wang, Jianwei Wang…

    Citation: Respiratory Research 2024 25:223

    Content type: Research Published on: 29 May 2024

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  • Clinical and prognostic associations of anti-Jo-1 antibody levels in patients with antisynthetase syndrome

    To investigate the association of serumanti-Jo-1 antibody levels with the disease activity and prognosis in anti-Jo-1-positive patients with antisynthetase syndrome (ASS).

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    Authors: Hongxia Yang, Qingning Chen, Chao Sun, Qiwen Jin, Lining Zhang, Qingyan Liu, Qinglin Peng, Guochun Wang and Xin Lu

    Citation: Respiratory Research 2024 25:222

    Content type: Research Published on: 29 May 2024

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  • Unveiling the metabolic landscape of pulmonary hypertension: insights from metabolomics

    Pulmonary hypertension (PH) is regarded as cardiovascular disease with an extremely poor prognosis, primarily due to irreversible vascular remodeling. Despite decades of research progress, the absence of defin...

    Authors: Huixue Ba, Yingfan Guo, Yujie Jiang, Ying Li, Xuejing Dai, Yuan Liu and Xiaohui Li

    Citation: Respiratory Research 2024 25:221

    Content type: Review Published on: 28 May 2024

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  • Identification of differentially expressed ER stress-related genes and their association with pulmonary arterial hypertension

    Pulmonary arterial hypertension (PAH) is a complex and progressive illness that has a multifaceted origin, significant fatality rates, and profound effects on health. The pathogenesis of PAH is poorly defined ...

    Authors: Qi Yang, Banghui Lai, Hao Xie, Mingbin Deng, Jun Li, Yan Yang, Juyi Wan, Bin Liao and Feng Liu

    Citation: Respiratory Research 2024 25:220

    Content type: Research Published on: 24 May 2024

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  • Rates of bronchopulmonary dysplasia in very low birth weight neonates: a systematic review and meta-analysis

    Large-scale estimates of bronchopulmonary dysplasia (BPD) are warranted for adequate prevention and treatment. However, systematic approaches to ascertain rates of BPD are lacking.

    Authors: Alvaro Moreira, Michelle Noronha, Jooby Joy, Noah Bierwirth, Aina Tarriela, Aliha Naqvi, Sarah Zoretic, Maxwell Jones, Ali Marotta, Taylor Valadie, Jonathan Brick, Caitlyn Winter, Melissa Porter, Isabelle Decker, Matteo Bruschettini and Sunil K. Ahuja

    Citation: Respiratory Research 2024 25:219

    Content type: Research Published on: 24 May 2024

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  • PD-1+ T lymphocyte proportions and hospitalized exacerbation of COPD: a prospective cohort study

    To evaluate the predictive value of PD-1 expression in T lymphocytes for rehospitalization due to acute exacerbations of COPD (AECOPD) in discharged patients.

    Authors: Hong Xue, Xiuyan Lan, Ting Xue, Xuwei Tang, Haitao Yang, Zhijian Hu, Nengluan Xu and Baosong Xie

    Citation: Respiratory Research 2024 25:218

    Content type: Research Published on: 24 May 2024

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  • Identifying potential drug targets for idiopathic pulmonary fibrosis: a mendelian randomization study based on the druggable genes

    Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic interstitial lung disease characterized by progressive dyspnea and decreased lung function, yet its exact etiology remains unclear. It is of great sign...

    Authors: Zetao Liu, Zhiyu Peng, Huahang Lin, Ke Zhou, Linchuan Liang, Jie Cao, Zhaokang Huang and Jiandong Mei

    Citation: Respiratory Research 2024 25:217

    Content type: Research Published on: 23 May 2024

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  • Improved pediatric ICU mortality prediction for respiratory diseases: machine learning and data subdivision insights

    The growing concern of pediatric mortality demands heightened preparedness in clinical settings, especially within intensive care units (ICUs). As respiratory-related admissions account for a substantial porti...

    Authors: Johayra Prithula, Muhammad E. H. Chowdhury, Muhammad Salman Khan, Khalid Al-Ansari, Susu M. Zughaier, Khandaker Reajul Islam and Abdulrahman Alqahtani

    Citation: Respiratory Research 2024 25:216

    Content type: Research Published on: 23 May 2024

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  • Combination of betulinic acid and EGFR-TKIs exerts synergistic anti-tumor effects against wild-type EGFR NSCLC by inducing autophagy-related cell death via EGFR signaling pathway

    Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of lung cancer patients with mutated EGFR. However, the efficacy of EGFR-TKIs in wild-type EGFR tumor...

    Authors: Han Wang, Xiaohui Du, Wenwen Liu, Congcong Zhang, Ying Li, Jingwen Hou, Yi Yu, Guiru Li and Qi Wang

    Citation: Respiratory Research 2024 25:215

    Content type: Research Published on: 20 May 2024

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    Respiratory Research (1)

  • Independent relationship between sleep apnea-specific hypoxic burden and glucolipid metabolism disorder: a cross-sectional study

    Obstructive sleep apnea (OSA) is associated with abnormal glucose and lipid metabolism. However, whether there is an independent association between Sleep Apnea-Specific Hypoxic Burden (SASHB) and glycolipid m...

    Authors: Chenyang Li, Yu Peng, Xiaoyue Zhu, Yupu Liu, Jianyin Zou, Huaming Zhu, Xinyi Li, Hongliang Yi, Jian Guan, Xu Zhang, Huajun Xu and Shankai Yin

    Citation: Respiratory Research 2024 25:214

    Content type: Research Published on: 18 May 2024

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  • Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice

    Obesity is associated with airway hyperresponsiveness and lung fibrosis, which may reduce the effectiveness of standard asthma treatment in individuals suffering from both conditions. Statins and proprotein co...

    Authors: Lin Liang, Sook In Chung, Tae-Eun Guon, Kyung Hee Park, Jae-Hyun Lee and Jung-Won Park

    Citation: Respiratory Research 2024 25:213

    Content type: Research Published on: 18 May 2024

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    Respiratory Research (2)

  • YAP/TAZ activation mediates PQ-induced lung fibrosis by sustaining senescent pulmonary epithelial cells

    Paraquat (PQ) is a widely used herbicide and a common cause of poisoning that leads to pulmonary fibrosis with a high mortality rate. However, the underlying mechanisms of PQ-induced pulmonary fibrosis and whe...

    Authors: Youjia Yu, Chunyan Chu, Kang Wang, Yan Li, Zhengsheng Mao, Li Hu, Jie Wang, Yanfang Yu, Hao Sun and Feng Chen

    Citation: Respiratory Research 2024 25:212

    Content type: Research Published on: 18 May 2024

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  • Comparative microbiome analysis in cystic fibrosis and non-cystic fibrosis bronchiectasis.

    Bronchiectasis is a condition characterized by abnormal and irreversible bronchial dilation resulting from lung tissue damage and can be categorized into two main groups: cystic fibrosis (CF) and non-CF bronch...

    Authors: Heryk Motta, Júlia Catarina Vieira Reuwsaat, Fernanda Cortez Lopes, Graciele Viezzer, Fabiana Caroline Zempulski Volpato, Afonso Luís Barth, Paulo de Tarso Roth Dalcin, Charley Christian Staats, Marilene Henning Vainstein and Lívia Kmetzsch

    Citation: Respiratory Research 2024 25:211

    Content type: Research Published on: 18 May 2024

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  • GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis

    Mitogen-activated protein kinase (MAPK)signaling-mediated smoking-associated pulmonary vascular remodeling (PVR) plays an important role in the pathogenesis of group 3 pulmonary hypertension (PH). And G protei...

    Authors: Ting Hu, Chaohui Mu, Yanmiao Li, Wanming Hao, Xinjuan Yu, Yixuan Wang, Wei Han and Qinghai Li

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    Citation: Respiratory Research 2024 25:210

    Content type: Research Published on: 16 May 2024

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    Respiratory Research (3)

  • Long COVID symptoms after 8-month recovery: persistent static lung hyperinflation associated with small airway dysfunction

    Limited research has investigated the relationship between small airway dysfunction (SAD) and static lung hyperinflation (SLH) in patients with post-acute sequelae of COVID-19 (PASC) especially dyspnea and fat...

    Authors: Po-Chun Lo, Jia-Yih Feng, Yi-Han Hsiao, Kang-Cheng Su, Kun-Ta Chou, Yuh-Min Chen, Hsin-Kuo Ko and Diahn-Warng Perng

    Citation: Respiratory Research 2024 25:209

    Content type: Research Published on: 15 May 2024

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  • The prevalence and mortality risks of PRISm and COPD in the United States from NHANES 2007–2012

    We estimated the prevalence and mortality risks of preserved ratio impaired spirometry (PRISm) and chronic obstructive pulmonary disease (COPD) in the US adult population.

    Authors: Christopher J. Cadham, Hayoung Oh, MeiLan K. Han, David Mannino, Steven Cook, Rafael Meza, David T. Levy and Luz María Sánchez-Romero

    Citation: Respiratory Research 2024 25:208

    Content type: Research Published on: 15 May 2024

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  • Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort

    The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD an...

    Authors: N. Frantzi, X. P. Nguyen, C. Herr, P. Alter, S. Söhler, D. Soriano, H. Watz, B. Waschki, F. Trinkmann, M. Eichenlaub, F. C. Trudzinski, J. D. Michels-Zetsche, A. Omlor, F. Seiler, I. Moneke, F. Biertz…

    Citation: Respiratory Research 2024 25:207

    Content type: Research Published on: 15 May 2024

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  • Machine-learning developed an iron, copper, and sulfur-metabolism associated signature predicts lung adenocarcinoma prognosis and therapy response

    Previous studies have largely neglected the role of sulfur metabolism in LUAD, and no study has combine iron, copper, and sulfur-metabolism associated genes together to create prognostic signatures.

    Authors: Liangyu Zhang, Xun Zhang, Maohao Guan, Jianshen Zeng, Fengqiang Yu and Fancai Lai

    Citation: Respiratory Research 2024 25:206

    Content type: Research Published on: 14 May 2024

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  • Acod1/itaconate activates Nrf2 in pulmonary microvascular endothelial cells to protect against the obesity-induced pulmonary microvascular endotheliopathy

    Obesity is the main risk factor leading to the development of various respiratory diseases, such as asthma and pulmonary hypertension. Pulmonary microvascular endothelial cells (PMVECs) play a significant role...

    Authors: Li Zhu, Zhuhua Wu, Yingli Liu, Yue Ming, Pei Xie, Miao Jiang and Yong Qi

    Citation: Respiratory Research 2024 25:205

    Content type: Research Published on: 10 May 2024

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  • Cigarette smoke-induced dysbiosis: comparative analysis of lung and intestinal microbiomes in COPD mice and patients

    The impact of cigarette smoke (CS) on lung diseases and the role of microbiome dysbiosis in chronic obstructive pulmonary disease (COPD) have been previously reported; however, the relationships remain unclear.

    Authors: Vincent Laiman, Hsiao-Chi Chuang, Yu-Chun Lo, Tzu-Hsuen Yuan, You-Yin Chen, Didik Setyo Heriyanto, Fara Silvia Yuliani, Kian Fan Chung and Jer-Hwa Chang

    Citation: Respiratory Research 2024 25:204

    Content type: Research Published on: 10 May 2024

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  • Cross-site validation of lung cancer diagnosis by electronic nose with deep learning: a multicenter prospective study

    Although electronic nose (eNose) has been intensively investigated for diagnosing lung cancer, cross-site validation remains a major obstacle to be overcome and no studies have yet been performed.

    Authors: Meng-Rui Lee, Mu-Hsiang Kao, Ya-Chu Hsieh, Min Sun, Kea-Tiong Tang, Jann-Yuan Wang, Chao-Chi Ho, Jin-Yuan Shih and Chong-Jen Yu

    Citation: Respiratory Research 2024 25:203

    Content type: Research Published on: 10 May 2024

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  • Mitochondrial DNA in bronchoalveolar lavage fluid is associated with the prognosis of idiopathic pulmonary fibrosis: a single cohort study

    Extracellular mitochondrial DNA (mtDNA) is released from damaged cells and increases in the serum and bronchoalveolar lavage fluid (BALF) of idiopathic pulmonary fibrosis (IPF) patients. While increased levels...

    Authors: Jun f*ckihara, Koji Sakamoto, Yoshiki Ikeyama, Taiki Furukawa, Ryo Teramachi, Kensuke Kataoka, Yasuhiro Kondoh, Naozumi Hashimoto and Makoto Ishii

    Citation: Respiratory Research 2024 25:202

    Content type: Research Published on: 10 May 2024

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  • GDF15 ameliorates sepsis-induced lung injury via AMPK-mediated inhibition of glycolysis in alveolar macrophage

    Growth differentiation factor 15 (GDF15) as a stress response cytokine is involved in the development and progression of several diseases associated with metabolic disorders. However, the regulatory role and t...

    Authors: Shasha Lu, Ranran Li, Yunxin Deng, Ju Bai, Bangqi Ji, Yufeng Chu, Yan Xu, Hongping Qu, Xiaosun Guo, Pibao Li and Mei Meng

    Citation: Respiratory Research 2024 25:201

    Content type: Research Published on: 9 May 2024

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  • Feasibility of restricting e-cigarettes to prescription only for smoking cessation

    E-cigarette use among youth in Canada has risen to epidemic proportions. E-cigarettes are also moderately useful smoking cessations aids. Restricting e-cigarettes to prescription only smoking cessation aids co...

    Authors: Katya Peri and Mark J. Eisenberg

    Citation: Respiratory Research 2024 25:200

    Content type: Comment Published on: 9 May 2024

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  • A comprehensive study on machine learning models combining with oversampling for bronchopulmonary dysplasia-associated pulmonary hypertension in very preterm infants

    Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) remains a devastating clinical complication seriously affecting the therapeutic outcome of preterm infants. Hence, early prevention and tim...

    Authors: Dan Wang, Shuwei Huang, Jingke Cao, Zhichun Feng, Qiannan Jiang, Wanxian Zhang, Jia Chen, Shelby Kutty, Changgen Liu, Wenyu Liao, Le Zhang, Guli Zhu, Wenhao Guo, Jie Yang, Lin Liu, Jingwei Yang…

    Citation: Respiratory Research 2024 25:199

    Content type: Research Published on: 8 May 2024

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  • Tuberculous pleural effusion-induced Arg-1+ macrophage polarization contributes to lung cancer progression via autophagy signaling

    The association between tuberculous fibrosis and lung cancer development has been reported by some epidemiological and experimental studies; however, its underlying mechanisms remain unclear, and the role of m...

    Authors: Seong Ji Woo, Youngmi Kim, Hyun-Jung Kang, Harry Jung, Dong Hyuk Youn, Yoonki Hong, Jae Jun Lee and Ji Young Hong

    Citation: Respiratory Research 2024 25:198

    Content type: Research Published on: 8 May 2024

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  • Predictors of moderate to severe obstructive sleep apnea in patients with lung cancer

    OSA is a known medical condition that is associated with several comorbidities and affect patients’ quality of life. The association between OSA and lung cancer remains debated. Some studies reported increased...

    Authors: Mohamed H. Zidan, Hany M. Shaarawy, Heba S. Gharraf, Suzan F. Helal, Maged Hassan and Rana Rizk

    Citation: Respiratory Research 2024 25:197

    Content type: Correspondence Published on: 7 May 2024

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  • Increased proportions of circulating PD-1+ CD4+ memory T cells and PD-1+ regulatory T cells associate with good response to prednisone in pulmonary sarcoidosis

    The treatment response to corticosteroids in patients with sarcoidosis is highly variable. CD4+ T cells are central in sarcoid pathogenesis and their phenotype in peripheral blood (PB) associates with disease cou...

    Authors: Jelle R. Miedema, Lieke J. de Jong, Vivienne Kahlmann, Ingrid M. Bergen, Caroline E. Broos, Marlies S. Wijsenbeek, Rudi W. Hendriks and Odilia B. J. Corneth

    Citation: Respiratory Research 2024 25:196

    Content type: Research Published on: 7 May 2024

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  • Lipocalin-2 as a prognostic marker in patients with acute exacerbation of idiopathic pulmonary fibrosis

    Lipocalin-2 (LCN2) is a secretory glycoprotein upregulated by oxidative stress; moreover, patients with idiopathic pulmonary fibrosis (IPF) have shown increased LCN2 levels in bronchoalveolar lavage fluid (BAL...

    Authors: Hiroki Tanahashi, Hiroshi Iwamoto, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Taku Nakashima, Shinichiro Ohshimo, Kazunori Fujitaka, Hironobu Hamada and Noboru Hattori

    Citation: Respiratory Research 2024 25:195

    Content type: Research Published on: 4 May 2024

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  • Objective monitoring tools for improved management of childhood asthma

    Asthma is a common chronic disease amongst children. Epidemiological studies showed that the mortality rate of asthma in children is still high worldwide. Asthma control is therefore essential to minimize asth...

    Authors: Phillip L.W. Au-Doung, Jason C.H. Chan, Oliver Y.H. Kui, Marco K.Y. Ho, Yin Ting Cheung, Jenny K.W. Lam, Hak-Kim Chan, John Brannan, Kate C.C. Chan, Albert M. Li and Sharon S.Y. Leung

    Citation: Respiratory Research 2024 25:194

    Content type: Review Published on: 3 May 2024

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  • Cooperation of immune regulators Tollip and surfactant protein A inhibits influenza A virus infection in mice

    Influenza A virus (IAV) infection is a significant risk factor for respiratory diseases, but the host defense mechanisms against IAV remain to be defined. Immune regulators such as surfactant protein A (SP-A) ...

    Authors: Niccolette Schaunaman, Diana Cervantes, Taylor Nichols, Mari Numata, Julie G. Ledford, Monica Kraft and Hong Wei Chu

    Citation: Respiratory Research 2024 25:193

    Content type: Research Published on: 3 May 2024

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  • Charting the cellular landscape of pulmonary arterial hypertension through single-cell omics

    This review examines how single-cell omics technologies, particularly single-cell RNA sequencing (scRNAseq), enhance our understanding of pulmonary arterial hypertension (PAH). PAH is a multifaceted disorder m...

    Authors: Brian Tang, Arjun Vadgama, Bryce Redmann and Jason Hong

    Citation: Respiratory Research 2024 25:192

    Content type: Review Published on: 3 May 2024

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  • Smoking status and clinical outcome in idiopathic pulmonary fibrosis: a nationwide study

    Smoking status has been linked to the development of idiopathic pulmonary fibrosis (IPF). However, the effect of smoking on the prognosis of patients with IPF is unclear. We aimed to investigate the associatio...

    Authors: Hee-Young Yoon, Hoseob Kim, Yoonjong Bae and Jin Woo Song

    Citation: Respiratory Research 2024 25:191

    Content type: Research Published on: 29 April 2024

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  • Acute respiratory failure due to pulmonary exacerbation in children with cystic fibrosis admitted in a pediatric intensive care unit: outcomes and factors associated with mortality

    Children with advanced pulmonary disease due to cystic fibrosis (CF) are at risk of acute respiratory failure due to pulmonary exacerbations leading to their admission to pediatric intensive care units (PICU)....

    Authors: David Drummond, Charlotte Roy, Matthieu Cornet, Julie Bucher, Véronique Boussaud, Françoise Le Pimpec-Barthes, Margaux Pontailler, Olivier Raisky, Vanessa Lopez, Claudio Barbanti, Romain Guillemain, Sylvain Renolleau, Marion Grimaud, Mehdi Oualha, Laure de Saint Blanquat and Isabelle Sermet-Gaudelus

    Citation: Respiratory Research 2024 25:190

    Content type: Research Published on: 29 April 2024

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  • Potential role of SIRT-1 and SIRT-3 as biomarkers for the diagnosis and prognosis of idiopathic pulmonary fibrosis

    Idiopathic pulmonary fibrosis (IPF) is a debilitating and progressive lung disease of unknown aetiology, characterized by the relentless deposition of fibrotic tissue. Biomarkers may play a pivotal role as ind...

    Authors: Fabio Perrotta, Vito D’Agnano, Domenica Francesca Mariniello, Giuseppe Castaldo, Maria Vitale, Mario Cazzola, Andrea Bianco and Filippo Scialò

    Citation: Respiratory Research 2024 25:189

    Content type: Research Published on: 27 April 2024

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  • TRPV2 modulates mechanically Induced ATP Release from Human bronchial epithelial cells

    Repetitive bouts of coughing expose the large airways to significant cycles of shear stress. This leads to the release of alarmins and the tussive agent adenosine triphosphate (ATP) which may be modulated by t...

    Authors: Orla M. Dunne, S. Lorraine Martin, Gerard P. Sergeant, Daniel F. McAuley, Cecilia M. O’Kane, Brian Button, Lorcan P. McGarvey and Fionnuala T. Lundy

    Citation: Respiratory Research 2024 25:188

    Content type: Research Published on: 27 April 2024

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  • Predicting lung function decline in cystic fibrosis: the impact of initiating ivacaftor therapy

    Modulator therapies that seek to correct the underlying defect in cystic fibrosis (CF) have revolutionized the clinical landscape. Given the heterogeneous nature of lung disease progression in the post-modulat...

    Authors: Grace C. Zhou, Ziyun Wang, Anushka K. Palipana, Eleni-Rosalina Andrinopoulou, Pedro Miranda Afonso, Gary L. McPhail, Christopher M. Siracusa, Emrah Gecili and Rhonda D. Szczesniak

    Citation: Respiratory Research 2024 25:187

    Content type: Research Published on: 27 April 2024

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  • Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis

    Influenza A viruses (IAV) are extremely common respiratory viruses for the acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in which IAV infection may further evoke abnormal macrophage pol...

    Authors: Meng-Meng Xu, Jia-Ying Kang, Qiu-Yan Wang, Xing Zuo, Yuan-Yuan Tan, Yuan-Yuan Wei, Da-Wei Zhang, Ling Zhang, Hui-Mei Wu and Guang-He Fei

    Citation: Respiratory Research 2024 25:186

    Content type: Original Article Published on: 27 April 2024

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    Respiratory Research (4)

  • Respiratory symptoms and outcomes among cigar smokers: findings from the Population Assessment of Tobacco and Health (PATH) study waves 2–5 (2014–2019)

    The mechanisms by which cigarette smoking increases the risk of respiratory disease have been studied. However, less is known about risks of respiratory symptoms and outcomes associated with smoking cigars, an...

    Authors: Eva Sharma, Kristin Lauten, Katarzyna A. Zebrak, Kathryn C. Edwards, Samantha VanEtten, Adam F. Benson, Cristine D. Delnevo, Daniela Marshall, Heather L. Kimmel, Kristie A. Taylor, Maansi Bansal-Travers, Andrew Hyland and K. Michael Cummings

    Citation: Respiratory Research 2024 25:185

    Content type: Research Published on: 27 April 2024

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    • Respiratory Research (2024)
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